Directional cell migration in vivo
نویسندگان
چکیده
منابع مشابه
Directional Sensing Orients Cell Migration and Polarization
Cell migration is a complex process that requires the coordinated regulation of the cytoskeleton and cell adhesion. Actin polymerization at the cell cortex generates filaments that produce pseudopods and other membrane extensions that provide forward drive (34). In unstimulated Dictyostelium cells, pseudopods are formed at random positions independently of receptors and G proteins (FIGURE 1). T...
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How spatial and temporal information are integrated to determine the direction of cell migration remains poorly understood. Here, by precise microfluidics emulation of dynamic chemoattractant waves, we demonstrate that, in Dictyostelium, directional movement as well as activation of small guanosine triphosphatase Ras at the leading edge is suppressed when the chemoattractant concentration is de...
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Epithelial reorganization involves coordinated changes in cell shapes and movements. This restructuring occurs during formation of placodes, ectodermal thickenings that initiate the morphogenesis of epithelial organs including hair, mammary gland, and tooth. Signaling pathways in ectodermal placode formation are well known, but the cellular mechanisms have remained ill defined. We established i...
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During embryonic development and in metastatic cancers, cells detach from the epithelium and migrate with persistent directionality. Directional cell migration is also crucial for the regeneration and maintenance of the epithelium and impaired directional migration is linked to chronic inflammatory diseases. Despite its significance, the mechanisms controlling epithelial cell migration remain p...
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Cell locomotion plays a key role in embryonic morphogenesis, wound healing, and cancer metastasis. Here we show that intermittent control of cell shape using microarrays can be used to amplify the natural directional persistence of cells and guide their continuous migration along preset paths and directions. The key to this geometry-based, gradient-free approach for directing cell migration is ...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2008
ISSN: 1933-6918,1933-6926
DOI: 10.4161/cam.2.4.6747